Postdoctoral Fellow - Poxvirus Research
- City of Hope
- Location: Duarte, CA
- Job Number: 7305242 (Ref #: 10029910)
- Posting Date: Newly posted
- Salary / Pay Rate: $34.00 - $37.55 / hour
- Application Deadline: Open Until Filled
Job Description
Join the forefront of groundbreaking research at theBeckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
A Postdoctoral Fellowship position is available in the Vaccine Research Laboratory of Dr. Don Diamond in the Department of Hematology & Hematopoietic Cell Transplantation. Dr. Diamond’s research team is seeking a highly motivated candidate with skills and understanding in antigen presentation utilizing bioinformatics tools to be applied to vaccine development utilizing viral vectors to contribute to an effort in developing neoantigen expressing vaccines for clinical investigations.
The position is available as part of a multi-disciplinary research project to develop a neoantigen-based cancer vaccines to support an IND utilizing a highly efficient and fully synthetic poxvirus-vectored vaccine platform that has been derisked by its use in Phase 2 clinical trials as a Covid-19 vaccine (see NCT04977024, NCT05672355, and NCT04639466). Please refer to these publications for further background: doi:10.3390/vaccines11091492, PMC7705736, PMC8906816, PMID33257686, PMID31739399 describing the platform and earlier publications using a p53-expressing MVA as a clinical therapeutic in cancer patients (10.1158/2767-9764.CRC-23-0394, PMC8802616, PMC5856606, and PMC5706612).
As a successful candidate you will:
· Have experience and knowledge of human and murine immunology, selection tools for predicting immunologic epitopes complementing virology skills (poxvirus molecular biology)
· Develop and characterize recombinant vaccine vectors incorporating neoantigens identified by proprietary bioinformatic pipelines and test these vaccine candidates for in vivo immunogenicity and protective efficacy in different animal tumor models leading to early phase clinical trials in pancreas, lung, and bladder tumor patients. The goal of these efforts is a start-up company utilizing GMP manufacturing to produce neoantigen vaccines for patients at medical centers nationally as a primary goal.
Your qualifications should include:
· PhD degree in an appropriate discipline such as cellular or tumor immunology or related fields
· Interest and knowledge in vaccine research (poxvirus especially) and neoantigen-based vaccine methods utilizing bioinformatics epitope selection pipelines.
· Experience in molecular virology methods, and antigen presentation and processing as applied to human and murine oncology.
· Ability to independently document scientific progress and write research articles.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
To learn more about our Comprehensive Benefits, pleaseCLICK HERE.
Salary / Pay Rate Information:
Pay Rate: $34.00 - $37.55 / hour
The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.
